Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy
نویسندگان
چکیده
منابع مشابه
Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy
Diabetic nephropathy (DN) is a frequent and severe complication of diabetes mellitus (DM). Its diagnosis in incipient stages may allow prompt interventions and an improved prognosis. Towards this aim, biomarkers for detecting early DN can be used. Microalbuminuria has been proven a remarkably useful biomarker, being used for diagnosis of DN, for assessing its associated condition-mainly cardiov...
متن کاملEarly urinary and plasma biomarkers for experimental diabetic nephropathy.
BACKGROUND As the prevalence of diabetes rises, its complications such as diabetic nephropathy affect an increaseing number of patients. Consequently, the need for biomarkers in rodent models which reflect the stage and course of diabetic nephropathy is high. This article focuses on Heart-type fatty acid binding protein (H-FABP), osteopontin (OPN), nephrin, and Neutrophil gelatinase-associated ...
متن کاملDiabetic Nephropathy: Emerging Biomarkers for Risk Assessment
Progression of diabetic nephropathy (DN) is commonly defined by an increase in albuminuria from normoalbuminuria to microalbuminuria and from microalbuminuria to macroalbuminuria. Although early detection of DN can prevent or slow its progression, a major difficulty in inducing remission in patients with early DN is the identification of biomarkers that could help identify patients more likely ...
متن کاملProteomic identification of urinary biomarkers of diabetic nephropathy.
OBJECTIVE Diabetic nephropathy is a serious complication of both type 1 and type 2 diabetes, and, unless arrested, leads to end-stage renal disease. Current diagnosis consists of urine assays of microalbuminuria, which have inadequate specificity and sensitivity. RESEARCH DESIGN AND METHODS We used proteomic analyses to identify novel biomarkers of nephropathy in urine from type 2 diabetic pa...
متن کاملAssessment of Urinary Osteopontin in Association with Podocyte for Early Predication of Nephropathy in Diabetic Patients
OBJECTIVES Microalbuminuria has been clinically used for noninvasive evaluation of renal dysfunctions. However, it is a nonspecific marker of diabetic nephropathy (DN). METHODS This study was conducted from March 2012 to April 2013 at Biochemistry Unit, King Fahd Medical Research Center (KFMRC). In this study, urinary osteopontin, podocytes number, and levels of immunoglobulin M (IgM) were de...
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ژورنال
عنوان ژورنال: Journal of Diabetes Research
سال: 2016
ISSN: 2314-6745,2314-6753
DOI: 10.1155/2016/4626125